2-Fluoro-4-iodobenzoic acid → HCID 71251867, compound

HRID 2411299Notes

Reaction equation

HRID 2411299 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([I:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.Cl.[CH:13]1([C:16]2[CH:17]=[C:18]([CH3:28])[C:19]([N:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)=[N:20][CH:21]=2)[CH2:15][CH2:14]1>>[CH:13]1([C:16]2[CH:17]=[C:18]([CH3:28])[C:19]([N:22]3[CH2:23][CH2:24][N:25]([C:4]([C:3]4[CH:7]=[CH:8][C:9]([I:11])=[CH:10][C:2]=4[F:1])=[O:6])[CH2:26][CH2:27]3)=[N:20][CH:21]=2)[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 27745162-Fluoro-4-iodobenzoic acidHCID 673810911-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride

Product 1

HCID 71251867HCID 71251867, compoundYield 95.8%

Procedure

Using 2-fluoro-4-iodobenzoic acid (399 mg) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride (381 mg) described in Preparation Example 82 and by the reaction and treatment in the same manner as in Preparation Example 160, the title compound (668.5 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 82 and by the reaction and treatment in the same manner as in Preparation Example 160

Sources & evidence

ORD record
ord-683f3d96dece45a9a3539ded5cf293a8
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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