1-(2,4-Xylyl)piperazine → (4-Bromo-3-chlorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone

HRID 2411307Notes

Reaction equation

HRID 2411307 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[Cl:11].[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:14]3[CH:15]=[CH:16][C:17]([CH3:19])=[CH:18][C:13]=3[CH3:12])[CH2:21][CH2:22]2)=[O:8])=[CH:4][C:3]=1[Cl:11]

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 125943024-Bromo-3-chlorobenzoic acid

Product 1

HCID 58484864(4-Bromo-3-chlorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanoneYield 100.7%

Procedure

Using 4-bromo-3-chlorobenzoic acid (2.4 g) and 1-(2,4-dimethylphenyl)piperazine (1.9 g) and by the reaction and treatment in the same manner as in Preparation Example 109, the title compound (4.1 g) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 109

Sources & evidence

ORD record
ord-32f3b19ad40745bd96c4b60a3039bff9
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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