6-Bromonicotinic acid → (6-Bromopyridin-3-yl)[4-(2,4,5-trimethylphenyl)piperazin-1-yl]methanone

HRID 2411309Notes

Reaction equation

HRID 2411309 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH3:11][C:12]1[CH:17]=[C:16]([CH3:18])[C:15]([CH3:19])=[CH:14][C:13]=1[N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:13]3[CH:14]=[C:15]([CH3:19])[C:16]([CH3:18])=[CH:17][C:12]=3[CH3:11])[CH2:21][CH2:22]2)=[O:8])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 2389326-Bromonicotinic acidHCID 27608211-(2,4,5-Trimethylphenyl)piperazine

Product 1

HCID 58484642(6-Bromopyridin-3-yl)[4-(2,4,5-trimethylphenyl)piperazin-1-yl]methanoneYield 101%

Procedure

Using 6-bromonicotinic acid (412 mg) and 1-(2,4,5-trimethylphenyl)piperazine (440 mg) and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (800 mg) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 118

Sources & evidence

ORD record
ord-ae60de3d44974732a98678e6e024a56f
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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