HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromonicotinic acid → (6-Bromopyridin-3-yl)[4-(2,4,5-trimethylphenyl)piperazin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromonicotinic acid | HCID 238932 | — |
| Reactant | 1-(2,4,5-Trimethylphenyl)piperazine | HCID 2760821 | — |
| Product | (6-Bromopyridin-3-yl)[4-(2,4,5-trimethylphenyl)piperazin-1-yl]methanone | HCID 58484642 | 101% |
Reaction Steps
Using 6-bromonicotinic acid (412 mg) and 1-(2,4,5-trimethylphenyl)piperazine (440 mg) and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (800 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-ae60de3d44974732a98678e6e024a56f |
| Source note | uspto-grants-2014_08 |