6-Fluoro-4-methylpyridine-3-carboxylic acid → HCID 71252523, compound

HRID 2411318Notes

Reaction equation

HRID 2411318 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH3:12][C:13]1[C:14]([N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[N:15][C:16]([CH3:20])=[C:17]([CH3:19])[CH:18]=1>>[F:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:24]2[CH2:25][CH2:26][N:21]([C:14]3[C:13]([CH3:12])=[CH:18][C:17]([CH3:19])=[C:16]([CH3:20])[N:15]=3)[CH2:22][CH2:23]2)=[O:8])=[C:9]([CH3:11])[CH:10]=1

Participants

3

Reactant 2

HCID 467392746-Fluoro-4-methylpyridine-3-carboxylic acidHCID 584848231-(3,5,6-Trimethylpyridin-2-yl)piperazine

Product 1

HCID 71252523HCID 71252523, compoundYield 83.8%

Procedure

Using 6-fluoro-4-methylnicotinic acid (119 mg) and 1-(3,5,6-trimethylpyridin-2-yl)piperazine (170 mg) described in Preparation Example 92 and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (220 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 92 and by the reaction and treatment in the same manner as in Preparation Example 118

Sources & evidence

ORD record
ord-e7b0abaab959490494408655ba015c9d
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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