2-Fluoro-4-iodobenzoic acid → [4-(3-Cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl](2-fluoro-4-iodophenyl)methanone

HRID 2411319Notes

Reaction equation

HRID 2411319 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([I:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.Cl.[CH:13]1([C:16]2[C:17]([N:23]3[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)=[N:18][CH:19]=[C:20]([CH3:22])[CH:21]=2)[CH2:15][CH2:14]1>>[CH:13]1([C:16]2[C:17]([N:23]3[CH2:28][CH2:27][N:26]([C:4]([C:3]4[CH:7]=[CH:8][C:9]([I:11])=[CH:10][C:2]=4[F:1])=[O:6])[CH2:25][CH2:24]3)=[N:18][CH:19]=[C:20]([CH3:22])[CH:21]=2)[CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 27745162-Fluoro-4-iodobenzoic acidHCID 673807751-(3-Cyclopropyl-5-methylpyridin-2-yl)piperazine hydrochloride

Product 1

HCID 71252370[4-(3-Cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl](2-fluoro-4-iodophenyl)methanoneYield 89.8%

Procedure

Using 2-fluoro-4-iodobenzoic acid (399 mg) and 1-(3-cyclopropyl-5-methylpyridin-2-yl)piperazine hydrochloride (381 mg) described in Preparation Example 85 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (627 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 85 and by the reaction and treatment in the same manner as in Preparation Example 111

Sources & evidence

ORD record
ord-a51ac731fc5b4cd281502a35884a33c1
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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