HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-4-iodobenzoic acid → [4-(3-Cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl](2-fluoro-4-iodophenyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-4-iodobenzoic acid | HCID 2774516 | — |
| Reactant | 1-(3-Cyclopropyl-5-methylpyridin-2-yl)piperazine hydrochloride | HCID 67380775 | — |
| Product | [4-(3-Cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl](2-fluoro-4-iodophenyl)methanone | HCID 71252370 | 89.8% |
Reaction Steps
Using 2-fluoro-4-iodobenzoic acid (399 mg) and 1-(3-cyclopropyl-5-methylpyridin-2-yl)piperazine hydrochloride (381 mg) described in Preparation Example 85 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (627 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-a51ac731fc5b4cd281502a35884a33c1 |
| Source note | uspto-grants-2014_08 |