4-Bromobenzoic acid → (4-Bromophenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

HRID 2411321Notes

Reaction equation

HRID 2411321 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][CH:3]=1.[CH:11]1([C:14]2[CH:15]=[C:16]([CH3:26])[C:17]([N:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)=[N:18][CH:19]=2)[CH2:13][CH2:12]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:17]3[C:16]([CH3:26])=[CH:15][C:14]([CH:11]4[CH2:12][CH2:13]4)=[CH:19][N:18]=3)[CH2:21][CH2:22]2)=[O:8])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 114644-Bromobenzoic acidHCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine

Product 1

HCID 71252330(4-Bromophenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanoneYield 70.4%

Procedure

Using 4-bromobenzoic acid (0.50 g) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (0.54 g) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (0.70 g) was obtained.

Workup

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Preparation Example 111

Sources & evidence

ORD record
ord-09e609c007df442e88ee576ed45fa8ea
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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