4-Iodobenzoyl chloride → [4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

HRID 2411322Notes

Reaction equation

HRID 2411322 reaction equation
[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:3][CH2:2]1.[I:19][C:20]1[CH:28]=[CH:27][C:23]([C:24](Cl)=[O:25])=[CH:22][CH:21]=1>>[CH:1]1([C:4]2[C:5]([N:13]3[CH2:14][CH2:15][N:16]([C:24]([C:23]4[CH:27]=[CH:28][C:20]([I:19])=[CH:21][CH:22]=4)=[O:25])[CH2:17][CH2:18]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 743734-Iodobenzoyl chlorideHCID 584847011-(3,5-Dicyclopropylpyridin-2-yl)piperazine

Product 1

HCID 58484688[4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanoneYield 90.9%

Procedure

Using 1-(3,5-dicyclopropylpyridin-2-yl)piperazine (5.52 g) described in Preparation Example 88 and 4-iodobenzoyl chloride (6.35 g) and by the reaction and treatment in the same manner as in Preparation Example 114, the title compound (9.76 g) was obtained.

Sources & evidence

ORD record
ord-2ed135829d5942ec92f2e00589bc9de4
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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