HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3,5-Dichloropyridin-2-yl)piperazine → [4-(3,5-Dichloropyridin-2-yl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-methanesulfonylphenyl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3,5-Dichloropyridin-2-yl)piperazine | HCID 2771431 | — |
| Reactant | 4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-methanesulfonylbenzoic acid | HCID 71252108 | — |
| Product | [4-(3,5-Dichloropyridin-2-yl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-methanesulfonylphenyl]methanone | HCID 71252471 | 12.8% |
Reaction Steps
Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-methanesulfonylbenzoic acid (319 mg) described in Preparation Example 22 and 1-(3,5-dichloropyridin-2-yl)piperazine (232 mg) and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (68 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-e0033eaad6b54f42b859f427584e2e65 |
| Source note | uspto-grants-2014_08 |