4-Bromobenzoic acid → HCID 71252713, compound

HRID 2411344Notes

Reaction equation

HRID 2411344 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][CH:3]=1.[CH2:11]([C:13]1[CH:14]=[C:15]([CH3:25])[C:16]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:17][CH:18]=1)[CH3:12]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([N:22]2[CH2:23][CH2:24][N:19]([C:16]3[C:15]([CH3:25])=[CH:14][C:13]([CH2:11][CH3:12])=[CH:18][N:17]=3)[CH2:20][CH2:21]2)=[O:8])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 114644-Bromobenzoic acidHCID 584845781-(5-Ethyl-3-methylpyridin-2-yl)piperazine

Product 1

HCID 71252713HCID 71252713, compoundYield 70.8%

Procedure

Using 4-bromobenzoic acid (1.01 g) and 1-(5-ethyl-3-methylpyridin-2-yl)piperazine (1.03 g) described in Preparation Example 81 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (1.38 g) was obtained.

Workup

  1. customdescribed in Preparation Example 81 and by the reaction and treatment in the same manner as in Preparation Example 111

Sources & evidence

ORD record
ord-33d0f8426b1840dfb0f5ded272a1a0a0
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…