5-Bromopyrimidine-2-carboxylic acid → HCID 71252096, compound

HRID 2411356Notes

Reaction equation

HRID 2411356 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[CH3:11][C:12]1[C:13]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:14][CH:15]=[C:16]([CH3:18])[CH:17]=1>>[Br:1][C:2]1[CH:7]=[N:6][C:5]([C:8]([N:22]2[CH2:23][CH2:24][N:19]([C:13]3[C:12]([CH3:11])=[CH:17][C:16]([CH3:18])=[CH:15][N:14]=3)[CH2:20][CH2:21]2)=[O:10])=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 164629705-Bromopyrimidine-2-carboxylic acidHCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazine

Product 1

HCID 71252096HCID 71252096, compoundYield 71.9%

Procedure

Using 5-bromopyrimidine-2-carboxylic acid (0.81 g) and 1-(3,5-dimethylpyridin-2-yl)piperazine (0.77 g) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (1.08 g) was obtained.

Workup

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 111

Sources & evidence

ORD record
ord-6497984e53794fdd9f106aa5384166cf
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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