5-Bromopyrazine-2-carboxylic acid → HCID 86676767, compound

HRID 2411359Notes

Reaction equation

HRID 2411359 reaction equation
[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[CH3:11][C:12]1[C:13]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:14][CH:15]=[C:16]([CH3:18])[CH:17]=1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([N:22]2[CH2:23][CH2:24][N:19]([C:13]3[C:12]([CH3:11])=[CH:17][C:16]([CH3:18])=[CH:15][N:14]=3)[CH2:20][CH2:21]2)=[O:10])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 187797905-Bromopyrazine-2-carboxylic acidHCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazine

Product 1

HCID 86676767HCID 86676767, compoundYield 69.5%

Procedure

Using 5-bromopyrazine-2-carboxylic acid (203 mg) and 1-(3,5-dimethylpyridin-2-yl)piperazine (191 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (261 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 118

Sources & evidence

ORD record
ord-ebbee38ada434d988d5ef2b3a423fe0b
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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