6-chloropyridazine-3-carboxylic Acid → HCID 86676768, compound

HRID 2411360Notes

Reaction equation

HRID 2411360 reaction equation
[Cl:1][C:2]1[N:7]=[N:6][C:5]([C:8]([OH:10])=O)=[CH:4][CH:3]=1.[CH:11]1([C:14]2[CH:15]=[C:16]([CH3:26])[C:17]([N:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)=[N:18][CH:19]=2)[CH2:13][CH2:12]1>>[Cl:1][C:2]1[N:7]=[N:6][C:5]([C:8]([N:23]2[CH2:24][CH2:25][N:20]([C:17]3[C:16]([CH3:26])=[CH:15][C:14]([CH:11]4[CH2:12][CH2:13]4)=[CH:19][N:18]=3)[CH2:21][CH2:22]2)=[O:10])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 64157626-chloropyridazine-3-carboxylic AcidHCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine

Product 1

HCID 86676768HCID 86676768, compoundYield 64.7%

Procedure

Using 6-chloropyridazine-3-carboxylic acid (1 g) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (1.37 g) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (1.46 g) was obtained.

Workup

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Preparation Example 118

Sources & evidence

ORD record
ord-5fdc8891184d4e0192c625fad05d8381
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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