2,4-Dibromobenzoic acid → [4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](2,4-dibromophenyl)methanone

HRID 2411365Notes

Reaction equation

HRID 2411365 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]([Br:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH:12]1([C:15]2[CH:16]=[C:17]([CH3:27])[C:18]([N:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)=[N:19][CH:20]=2)[CH2:14][CH2:13]1>>[CH:12]1([C:15]2[CH:16]=[C:17]([CH3:27])[C:18]([N:21]3[CH2:22][CH2:23][N:24]([C:4]([C:3]4[CH:7]=[CH:8][C:9]([Br:11])=[CH:10][C:2]=4[Br:1])=[O:6])[CH2:25][CH2:26]3)=[N:19][CH:20]=2)[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 118962,4-Dibromobenzoic acidHCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine

Product 1

HCID 71252039[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](2,4-dibromophenyl)methanoneYield 69.4%

Procedure

Using 2,4-dibromobenzoic acid (530 mg) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (413 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (630 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Preparation Example 118

Sources & evidence

ORD record
ord-454dbf25e8c64176a8b60eaa061ad254
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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