5-Bromothiophene-3-carboxylic acid → HCID 71252690, compound

HRID 2411371Notes

Reaction equation

HRID 2411371 reaction equation
[Br:1][C:2]1[S:6][CH:5]=[C:4]([C:7]([OH:9])=O)[CH:3]=1.[CH3:10][C:11]1[C:12]([N:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)=[N:13][CH:14]=[C:15]([CH3:17])[CH:16]=1>>[Br:1][C:2]1[S:6][CH:5]=[C:4]([C:7]([N:21]2[CH2:22][CH2:23][N:18]([C:12]3[C:11]([CH3:10])=[CH:16][C:15]([CH3:17])=[CH:14][N:13]=3)[CH2:19][CH2:20]2)=[O:9])[CH:3]=1

Participants

3

Reactant 2

HCID 120399785-Bromothiophene-3-carboxylic acidHCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazine

Product 1

HCID 71252690HCID 71252690, compoundYield 76.2%

Procedure

Using 5-bromothiophene-3-carboxylic acid (500 mg) and 1-(3,5-dimethylpyridin-2-yl)piperazine (462 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (700 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 118

Sources & evidence

ORD record
ord-5214d9748300452fb47c2cfa6ea70dd0
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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