4-Bromo-2-cyanobenzoic acid → HCID 71252294, compound

HRID 2411372Notes

Reaction equation

HRID 2411372 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([C:11]#[N:12])[CH:3]=1.[CH:13]1([C:16]2[C:17]([N:25]3[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]3)=[N:18][CH:19]=[C:20]([CH:22]3[CH2:24][CH2:23]3)[CH:21]=2)[CH2:15][CH2:14]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:28]2[CH2:29][CH2:30][N:25]([C:17]3[C:16]([CH:13]4[CH2:14][CH2:15]4)=[CH:21][C:20]([CH:22]4[CH2:24][CH2:23]4)=[CH:19][N:18]=3)[CH2:26][CH2:27]2)=[O:8])=[C:4]([CH:3]=1)[C:11]#[N:12]

Participants

3

Reactant 2

HCID 584845854-Bromo-2-cyanobenzoic acidHCID 584847011-(3,5-Dicyclopropylpyridin-2-yl)piperazine

Product 1

HCID 71252294HCID 71252294, compoundYield 92.8%

Procedure

Using 4-bromo-2-cyanobenzoic acid (3.39 g) described in Preparation Example 76 and 1-(3,5-dicyclopropylpyridin-2-yl)piperazine (4.02 g) described in Preparation Example 88 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (6.28 g) was obtained.

Workup

  1. customdescribed in Preparation Example 88 and by the reaction and treatment in the same manner as in Preparation Example 111

Sources & evidence

ORD record
ord-fd861d89ed314b11b3da05938404b7e7
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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