1-(3,5,6-Trimethylpyridin-2-yl)piperazine → HCID 86676770, compound

HRID 2411375Notes

Reaction equation

HRID 2411375 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([CH3:11])[N:3]=1.[CH3:12][C:13]1[C:14]([N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[N:15][C:16]([CH3:20])=[C:17]([CH3:19])[CH:18]=1>>[Br:1][C:2]1[N:3]=[C:4]([CH3:11])[C:5]([C:6]([N:24]2[CH2:25][CH2:26][N:21]([C:14]3[C:13]([CH3:12])=[CH:18][C:17]([CH3:19])=[C:16]([CH3:20])[N:15]=3)[CH2:22][CH2:23]2)=[O:8])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 584848231-(3,5,6-Trimethylpyridin-2-yl)piperazineHCID 716915676-BroMo-2-Methyl-nicotinic acid

Product 1

HCID 86676770HCID 86676770, compoundYield 57.6%

Procedure

Using 6-bromo-2-methylnicotinic acid (745 mg) and 1-(3,5,6-trimethylpyridin-2-yl)piperazine (744 mg) described in Preparation Example 92 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (801 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 92 and by the reaction and treatment in the same manner as in Preparation Example 111

Sources & evidence

ORD record
ord-bc26cdaed84441f68bcbf6c12ae08ce2
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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