1-(5-Ethyl-3-methylpyridin-2-yl)piperazine → HCID 86676772, compound

HRID 2411377Notes

Reaction equation

HRID 2411377 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([CH3:11])[N:3]=1.[CH2:12]([C:14]1[CH:15]=[C:16]([CH3:26])[C:17]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:18][CH:19]=1)[CH3:13]>>[Br:1][C:2]1[N:3]=[C:4]([CH3:11])[C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:17]3[C:16]([CH3:26])=[CH:15][C:14]([CH2:12][CH3:13])=[CH:19][N:18]=3)[CH2:21][CH2:22]2)=[O:8])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 584845781-(5-Ethyl-3-methylpyridin-2-yl)piperazineHCID 716915676-BroMo-2-Methyl-nicotinic acid

Product 1

HCID 86676772HCID 86676772, compoundYield 55.3%

Procedure

Using 6-bromo-2-methylnicotinic acid (675 mg) and 1-(5-ethyl-3-methylpyridin-2-yl)piperazine (611 mg) described in Preparation Example 81 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (664 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 81 and by the reaction and treatment in the same manner as in Preparation Example 111

Sources & evidence

ORD record
ord-cb5b380073784858b412fff030a14dbb
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…