1-(3,5-Dicyclopropylpyridin-2-yl)piperazine → HCID 86676773, compound

HRID 2411378Notes

Reaction equation

HRID 2411378 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([CH3:11])[N:3]=1.[CH:12]1([C:15]2[C:16]([N:24]3[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)=[N:17][CH:18]=[C:19]([CH:21]3[CH2:23][CH2:22]3)[CH:20]=2)[CH2:14][CH2:13]1>>[Br:1][C:2]1[N:3]=[C:4]([CH3:11])[C:5]([C:6]([N:27]2[CH2:28][CH2:29][N:24]([C:16]3[C:15]([CH:12]4[CH2:13][CH2:14]4)=[CH:20][C:19]([CH:21]4[CH2:23][CH2:22]4)=[CH:18][N:17]=3)[CH2:25][CH2:26]2)=[O:8])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 584847011-(3,5-Dicyclopropylpyridin-2-yl)piperazineHCID 716915676-BroMo-2-Methyl-nicotinic acid

Product 1

HCID 86676773HCID 86676773, compoundYield 56.3%

Procedure

Using 6-bromo-2-methylnicotinic acid (604 mg) and 1-(3,5-dicyclopropylpyridin-2-yl)piperazine (816 mg) described in Preparation Example 88 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (695 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 88 and by the reaction and treatment in the same manner as in Preparation Example 111

Sources & evidence

ORD record
ord-6585959be48d431faace28190830358e
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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