3,5-Dimethyl-2,4-Imidazolidinedione → Methyl 6-(3,5-dimethyl-2,4-dioxoimidazolidin-1-yl)-2-methylnicotinate

HRID 2411382Notes

Reaction equation

HRID 2411382 reaction equation
Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH3:12])[N:3]=1.[CH3:13][N:14]1[C:18](=[O:19])[CH:17]([CH3:20])[NH:16][C:15]1=[O:21]>>[CH3:13][N:14]1[C:18](=[O:19])[CH:17]([CH3:20])[N:16]([C:2]2[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH3:12])[N:3]=2)[C:15]1=[O:21]

Participants

3

Reactant 2

HCID 101540613,5-Dimethyl-2,4-ImidazolidinedioneHCID 71691566Methyl 6-bromo-2-methylpyridine-3-carboxylate

Product 1

HCID 71252642Methyl 6-(3,5-dimethyl-2,4-dioxoimidazolidin-1-yl)-2-methylnicotinateYield 16.4%

Procedure

Using methyl 6-bromo-2-methylnicotinate (96 mg) and 3,5-dimethylimidazolidine-2,4-dione (107 mg) described in Preparation Example 217 and by the reaction and treatment in the same manner as in Preparation Example 48, the title compound (19 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 217 and by the reaction and treatment in the same manner as in Preparation Example 48

Sources & evidence

ORD record
ord-c55045bd276a4ea2bea0320410589f0a
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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