2-Bromo-4-chlorobenzoic acid → HCID 71253010, compound

HRID 2411384Notes

Reaction equation

HRID 2411384 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:12][C:13]1[C:14]([N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[N:15][C:16]([CH3:20])=[C:17]([CH3:19])[CH:18]=1>>[Br:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([N:24]1[CH2:25][CH2:26][N:21]([C:14]2[C:13]([CH3:12])=[CH:18][C:17]([CH3:19])=[C:16]([CH3:20])[N:15]=2)[CH2:22][CH2:23]1)=[O:6]

Participants

3

Reactant 2

HCID 331262-Bromo-4-chlorobenzoic acidHCID 584848231-(3,5,6-Trimethylpyridin-2-yl)piperazine

Product 1

HCID 71253010HCID 71253010, compoundYield 103.3%

Procedure

Using 2-bromo-4-chlorobenzoic acid (1 g) and 1-(3,5,6-trimethylpyridin-2-yl)piperazine (0.87 g) described in Preparation Example 92 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (1.85 g) was obtained.

Workup

  1. customdescribed in Preparation Example 92 and by the reaction and treatment in the same manner as in Preparation Example 111

Sources & evidence

ORD record
ord-3fa8c7e48c5f4af4b9eed2d203db6d49
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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