[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone → HCID 71253082, compound

HRID 2411388Notes

Reaction equation

HRID 2411388 reaction equation
[CH2:1]([C@@H:3]1[CH2:7][CH2:6][S:5](=[O:9])(=[O:8])[NH:4]1)[CH3:2].[CH3:10][C:11]1[C:12]([N:18]2[CH2:23][CH2:22][N:21]([C:24]([C:26]3[CH:31]=[CH:30][C:29](I)=[CH:28][CH:27]=3)=[O:25])[CH2:20][CH2:19]2)=[N:13][CH:14]=[C:15]([CH3:17])[CH:16]=1>>[CH3:10][C:11]1[C:12]([N:18]2[CH2:19][CH2:20][N:21]([C:24]([C:26]3[CH:31]=[CH:30][C:29]([N:4]4[C@H:3]([CH2:1][CH3:2])[CH2:7][CH2:6][S:5]4(=[O:9])=[O:8])=[CH:28][CH:27]=3)=[O:25])[CH2:22][CH2:23]2)=[N:13][CH:14]=[C:15]([CH3:17])[CH:16]=1

Participants

3

Reactant 2

HCID 58484535[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanoneHCID 86676750HCID 86676750, compound

Product 1

HCID 71253082HCID 71253082, compoundYield 12.9%

Procedure

Using (R)-3-ethylisothiazolidine 1,1-dioxide (150 mg) described in Preparation Example 3 and [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (421 mg) described in Preparation Example 113 and by the reaction and treatment in the same manner as in Example 1, the title compound (57 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 113 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-bfbd4945fcde464685b19661fcd24763
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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