[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone → (S)-[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl][4-(4-methyl-1,1-dioxo-1lambda6-isothiazolidin-2-yl)phenyl]methanone

HRID 2411392Notes

Reaction equation

HRID 2411392 reaction equation
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20](I)=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[CH3:24][C@@H:25]1[CH2:29][S:28](=[O:31])(=[O:30])[NH:27][CH2:26]1>>[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:27]4[CH2:26][C@H:25]([CH3:24])[CH2:29][S:28]4(=[O:31])=[O:30])=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

3

Reactant 2

HCID 58484535[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanoneHCID 86676774(S)-4-methylisothiazolidine 1,1-dioxide

Product 1

HCID 71252550(S)-[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl][4-(4-methyl-1,1-dioxo-1lambda6-isothiazolidin-2-yl)phenyl]methanoneYield 24.2%

Procedure

Using [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (130 mg) described in Preparation Example 113 and (S)-4-methylisothiazolidine 1,1-dioxide (84 mg) described in Preparation Example 4 and by the reaction and treatment in the same manner as in Example 1, the title compound (32 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 4 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-d058c7fe4a744506a56d81f2ff3e0516
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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