Methyl p-toluenesulfonate → HCID 71251898, compound

HRID 2411419Notes

Reaction equation

HRID 2411419 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[CH:22]=[CH:21][C:20]([N:23]3[C@H:27]([CH2:28][OH:29])[CH2:26][CH2:25][S:24]3(=[O:31])=[O:30])=[CH:19][CH:18]=2)=[O:16])[CH2:11][CH2:10]1.S(C1C=CC(C)=CC=1)(O[CH3:36])(=O)=O>>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:10][CH2:11][N:12]([C:15]([C:17]2[CH:18]=[CH:19][C:20]([N:23]3[C@H:27]([CH2:28][O:29][CH3:36])[CH2:26][CH2:25][S:24]3(=[O:30])=[O:31])=[CH:21][CH:22]=2)=[O:16])[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 6645Methyl p-toluenesulfonateHCID 71252751HCID 71252751, compound

Product 1

HCID 71251898HCID 71251898, compound

Procedure

Using (S)-[4-(2,4-dimethylphenyl)piperazin-1-yl][4-(3-hydroxymethyl-1,1-dioxo-1λ6-isothiazolidin-2-yl)phenyl]methanone (480 mg) described in Example 32 and methyl tosylate (0.16 mL) and by the reaction and treatment in the same manner as in Example 36, the title compound (177 mg) was obtained.

Sources & evidence

ORD record
ord-ae4cad4d11cc4191a8a71518b13dcca4
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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