HCID 16664117, compound → HCID 71252414, compound

HRID 2411421Notes

Reaction equation

HRID 2411421 reaction equation
C([O:8][CH2:9][C@@H:10]1[CH2:14][CH2:13][S:12](=[O:16])(=[O:15])[NH:11]1)C1C=CC=CC=1.Br[C:18]1[CH:23]=[CH:22][C:21]([C:24]([N:26]2[CH2:31][CH2:30][N:29]([C:32]3[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][C:33]=3[CH3:39])[CH2:28][CH2:27]2)=[O:25])=[C:20]([F:40])[CH:19]=1>>[CH3:39][C:33]1[CH:34]=[C:35]([CH3:38])[CH:36]=[CH:37][C:32]=1[N:29]1[CH2:28][CH2:27][N:26]([C:24]([C:21]2[CH:22]=[CH:23][C:18]([N:11]3[C@H:10]([CH2:9][OH:8])[CH2:14][CH2:13][S:12]3(=[O:15])=[O:16])=[CH:19][C:20]=2[F:40])=[O:25])[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 16664117HCID 16664117, compoundHCID 58484705(4-Bromo-2-fluorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone

Product 1

HCID 71252414HCID 71252414, compoundYield 60.5%

Procedure

Using (S)-3-benzyloxymethylisothiazolidine 1,1-dioxide (536 mg) described in Preparation Example 1 and (4-bromo-2-fluorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (869 mg) described in Preparation Example 116 and by the reaction and treatment in the same manner as in Example 32, the title compound (620 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 116 and by the reaction and treatment in the same manner as in Example 32

Sources & evidence

ORD record
ord-25506b02fd7f465b88684dbd3cebc1c5
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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