Methyl p-toluenesulfonate → HCID 71252154, compound

HRID 2411422Notes

Reaction equation

HRID 2411422 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[CH:22]=[CH:21][C:20]([N:23]3[C@H:27]([CH2:28][OH:29])[CH2:26][CH2:25][S:24]3(=[O:31])=[O:30])=[CH:19][C:18]=2[F:32])=[O:16])[CH2:11][CH2:10]1.S(C1C=CC(C)=CC=1)(O[CH3:37])(=O)=O>>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:10][CH2:11][N:12]([C:15]([C:17]2[CH:22]=[CH:21][C:20]([N:23]3[C@H:27]([CH2:28][O:29][CH3:37])[CH2:26][CH2:25][S:24]3(=[O:30])=[O:31])=[CH:19][C:18]=2[F:32])=[O:16])[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 6645Methyl p-toluenesulfonateHCID 71252414HCID 71252414, compound

Product 1

HCID 71252154HCID 71252154, compound

Procedure

Using (S)-[4-(2,4-dimethylphenyl)piperazin-1-yl][2-fluoro-4-(3-hydroxymethyl-1,1-dioxo-1λ6-isothiazolidin-2-yl)phenyl]methanone (550 mg) described in Example 39 and methyl tosylate (0.18 mL) and by the reaction and treatment in the same manner as in Example 36, the title compound (48 mg) was obtained.

Sources & evidence

ORD record
ord-ddfb0e99ddd04d87834d628b1d443c99
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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