HCID 71251940, compound → HCID 71252335, compound

HRID 2411426Notes

Reaction equation

[CH3:1][C@@H:2]1[CH2:6][S:5](=[O:8])(=[O:7])[NH:4][CH2:3]1.[CH:9]1([C:12]2[C:13]([N:21]3[CH2:26][CH2:25][N:24]([C:27]([C:29]4[CH:34]=[CH:33][C:32](I)=[CH:31][C:30]=4[F:36])=[O:28])[CH2:23][CH2:22]3)=[N:14][CH:15]=[C:16]([CH:18]3[CH2:20][CH2:19]3)[CH:17]=2)[CH2:11][CH2:10]1>>[CH:9]1([C:12]2[C:13]([N:21]3[CH2:22][CH2:23][N:24]([C:27]([C:29]4[CH:34]=[CH:33][C:32]([N:4]5[CH2:3][C@H:2]([CH3:1])[CH2:6][S:5]5(=[O:8])=[O:7])=[CH:31][C:30]=4[F:36])=[O:28])[CH2:25][CH2:26]3)=[N:14][CH:15]=[C:16]([CH:18]3[CH2:20][CH2:19]3)[CH:17]=2)[CH2:10][CH2:11]1

Participants

Reactant 2

HCID 71251940HCID 71251940, compound

HCID 86676774(S)-4-methylisothiazolidine 1,1-dioxide

Product 1

HCID 71252335HCID 71252335, compoundYield 32.8%

Procedure

Using (S)-4-methylisothiazolidine 1,1-dioxide (235 mg) described in Preparation Example 4 and [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl](2-fluoro-4-iodophenyl)methanone (570 mg) described in Preparation Example 164 and by the reaction and treatment in the same manner as in Example 1, the title compound (190 mg) was obtained.

Workup

customdescribed in Preparation Example 164 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record: ord-fc4599ca30684e83840c3540305cf617
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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