(4-Iodophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone → HCID 71252168, compound

HRID 2411429Notes

Reaction equation

HRID 2411429 reaction equation
[CH3:1][C@@H:2]1[CH2:6][S:5](=[O:8])(=[O:7])[NH:4][CH2:3]1.I[C:10]1[CH:15]=[CH:14][C:13]([C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH3:30])=[CH:28][C:27]([CH3:31])=[C:26]([CH3:32])[N:25]=3)[CH2:20][CH2:19]2)=[O:17])=[CH:12][CH:11]=1>>[CH3:1][C@@H:2]1[CH2:6][S:5](=[O:8])(=[O:7])[N:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([N:18]3[CH2:23][CH2:22][N:21]([C:24]4[C:29]([CH3:30])=[CH:28][C:27]([CH3:31])=[C:26]([CH3:32])[N:25]=4)[CH2:20][CH2:19]3)=[O:17])=[CH:12][CH:11]=2)[CH2:3]1

Participants

3

Reactant 2

HCID 58484793(4-Iodophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 86676774(S)-4-methylisothiazolidine 1,1-dioxide

Product 1

HCID 71252168HCID 71252168, compoundYield 55%

Procedure

Using (S)-4-methylisothiazolidine 1,1-dioxide (90 mg) described in Preparation Example 4 and (4-iodophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (193 mg) described in Preparation Example 120 and by the reaction and treatment in the same manner as in Example 4, the title compound (108 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 120 and by the reaction and treatment in the same manner as in Example 4

Sources & evidence

ORD record
ord-a61426260e284f2a8afb7ef3166e6570
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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