(4-Bromo-2-fluorophenyl)[4-(3-cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]methanone → HCID 71252095, 화합물

HRID 2411433노트

반응식

HRID 2411433 반응식
[CH3:1][C@@H:2]1[CH2:6][S:5](=[O:8])(=[O:7])[NH:4][CH2:3]1.Br[C:10]1[CH:15]=[CH:14][C:13]([C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH:30]4[CH2:32][CH2:31]4)=[CH:28][C:27]([C:33]([F:36])([F:35])[F:34])=[CH:26][N:25]=3)[CH2:20][CH2:19]2)=[O:17])=[C:12]([F:37])[CH:11]=1>>[CH:30]1([C:29]2[C:24]([N:21]3[CH2:20][CH2:19][N:18]([C:16]([C:13]4[CH:14]=[CH:15][C:10]([N:4]5[CH2:3][C@H:2]([CH3:1])[CH2:6][S:5]5(=[O:8])=[O:7])=[CH:11][C:12]=4[F:37])=[O:17])[CH2:23][CH2:22]3)=[N:25][CH:26]=[C:27]([C:33]([F:35])([F:36])[F:34])[CH:28]=2)[CH2:32][CH2:31]1

참가 물질

3

반응물 2

HCID 58484690(4-Bromo-2-fluorophenyl)[4-(3-cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 86676774HCID 86676774, 화합물

생성물 1

HCID 71252095HCID 71252095, 화합물수율 57.5%

실험 절차

Using (S)-4-methylisothiazolidine 1,1-dioxide (110 mg) described in Preparation Example 4 and (4-bromo-2-fluorophenyl)[4-(3-cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]methanone (256 mg) described in Preparation Example 123 and by the reaction and treatment in the same manner as in Example 4, the title compound (164 mg) was obtained.

후처리

  1. customdescribed in Preparation Example 123 and by the reaction and treatment in the same manner as in Example 4

출처 및 근거

ORD 기록
ord-124d20e68ac54d14a36d925d6dc3a282
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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