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(4-Bromo-2-fluorophenyl)[4-(3-cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]methanone → HCID 71252095、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (4-Bromo-2-fluorophenyl)[4-(3-cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484690 | — |
| 反応物 | HCID 86676774 | HCID 86676774 | — |
| 生成物 | HCID 71252095 | HCID 71252095 | 57.5% |
反応手順
Using (S)-4-methylisothiazolidine 1,1-dioxide (110 mg) described in Preparation Example 4 and (4-bromo-2-fluorophenyl)[4-(3-cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]methanone (256 mg) described in Preparation Example 123 and by the reaction and treatment in the same manner as in Example 4, the title compound (164 mg) was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08816079B2 |
| 出典データセット | uspto-grants-2014_08 |
| ORD ID | ord-124d20e68ac54d14a36d925d6dc3a282 |
| 出典メモ | uspto-grants-2014_08 |