HCID 16664117, compound → HCID 71252868, compound

HRID 2411449Notes

Reaction equation

HRID 2411449 reaction equation
C([O:8][CH2:9][C@@H:10]1[CH2:14][CH2:13][S:12](=[O:16])(=[O:15])[NH:11]1)C1C=CC=CC=1.[CH:17]1([C:20]2[CH:21]=[C:22]([CH3:41])[C:23]([N:26]3[CH2:31][CH2:30][N:29]([C:32]([C:34]4[CH:39]=[CH:38][C:37](I)=[CH:36][CH:35]=4)=[O:33])[CH2:28][CH2:27]3)=[N:24][CH:25]=2)[CH2:19][CH2:18]1>>[CH:17]1([C:20]2[CH:21]=[C:22]([CH3:41])[C:23]([N:26]3[CH2:31][CH2:30][N:29]([C:32]([C:34]4[CH:39]=[CH:38][C:37]([N:11]5[C@H:10]([CH2:9][OH:8])[CH2:14][CH2:13][S:12]5(=[O:15])=[O:16])=[CH:36][CH:35]=4)=[O:33])[CH2:28][CH2:27]3)=[N:24][CH:25]=2)[CH2:18][CH2:19]1

Participants

3

Reactant 2

HCID 16664117HCID 16664117, compoundHCID 58484841[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 71252868HCID 71252868, compoundYield 37.9%

Procedure

Using (S)-3-benzyloxymethylisothiazolidine 1,1-dioxide (241 mg) described in Preparation Example 1 and [4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (447 mg) described in Preparation Example 117 and by the reaction and treatment in the same manner as in Example 32, the title compound (178 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 117 and by the reaction and treatment in the same manner as in Example 32

Sources & evidence

ORD record
ord-09a3b385d12544bcafa66f801c376fb8
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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