[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone → [4-(3,3-Dimethyl-1,1-dioxo-1lambda6-isothiazolidin-2-yl)phenyl][4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

HRID 2411454Notes

Reaction equation

HRID 2411454 reaction equation
[CH3:1][C:2]1([CH3:9])[CH2:6][CH2:5][S:4](=[O:8])(=[O:7])[NH:3]1.[CH3:10][C:11]1[C:12]([N:18]2[CH2:23][CH2:22][N:21]([C:24]([C:26]3[CH:31]=[CH:30][C:29](I)=[CH:28][CH:27]=3)=[O:25])[CH2:20][CH2:19]2)=[N:13][CH:14]=[C:15]([CH3:17])[CH:16]=1>>[CH3:1][C:2]1([CH3:9])[CH2:6][CH2:5][S:4](=[O:8])(=[O:7])[N:3]1[C:29]1[CH:30]=[CH:31][C:26]([C:24]([N:21]2[CH2:22][CH2:23][N:18]([C:12]3[C:11]([CH3:10])=[CH:16][C:15]([CH3:17])=[CH:14][N:13]=3)[CH2:19][CH2:20]2)=[O:25])=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 58484535[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanoneHCID 596494563,3-Dimethyl-1lambda6,2-thiazolidine-1,1-dione

Product 1

HCID 71252412[4-(3,3-Dimethyl-1,1-dioxo-1lambda6-isothiazolidin-2-yl)phenyl][4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneYield 1.3%

Procedure

Using 3,3-dimethylisothiazolidine 1,1-dioxide (130 mg) described in Preparation Example 11 and [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (367 mg) described in Preparation Example 113 and by the reaction and treatment in the same manner as in Example 1, the title compound (4.9 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 113 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-1d8430379d524afb9a58432a691c3bac
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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