HuagongsheHuagongshe Chemistry Print Report · For research reference only
[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone → [4-(3,3-Dimethyl-1,1-dioxo-1lambda6-isothiazolidin-2-yl)phenyl][4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone | HCID 58484535 | — |
| Reactant | 3,3-Dimethyl-1lambda6,2-thiazolidine-1,1-dione | HCID 59649456 | — |
| Product | [4-(3,3-Dimethyl-1,1-dioxo-1lambda6-isothiazolidin-2-yl)phenyl][4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone | HCID 71252412 | 1.3% |
Reaction Steps
Using 3,3-dimethylisothiazolidine 1,1-dioxide (130 mg) described in Preparation Example 11 and [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (367 mg) described in Preparation Example 113 and by the reaction and treatment in the same manner as in Example 1, the title compound (4.9 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-1d8430379d524afb9a58432a691c3bac |
| Source note | uspto-grants-2014_08 |