1-(2,6-Dimethylpyridin-3-yl)piperazine → HCID 71252314, compound

HRID 2411485Notes

Reaction equation

HRID 2411485 reaction equation
[O:1]=[S:2]1(=[O:20])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[C:9]([S:16]([CH3:19])(=[O:18])=[O:17])[CH:8]=1.[CH3:21][C:22]1[C:27]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[CH:26][CH:25]=[C:24]([CH3:34])[N:23]=1>>[CH3:21][C:22]1[C:27]([N:28]2[CH2:33][CH2:32][N:31]([C:11]([C:10]3[CH:14]=[CH:15][C:7]([N:3]4[CH2:4][CH2:5][CH2:6][S:2]4(=[O:1])=[O:20])=[CH:8][C:9]=3[S:16]([CH3:19])(=[O:18])=[O:17])=[O:13])[CH2:30][CH2:29]2)=[CH:26][CH:25]=[C:24]([CH3:34])[N:23]=1

Participants

3

Reactant 2

HCID 584847031-(2,6-Dimethylpyridin-3-yl)piperazineHCID 712521084-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-methanesulfonylbenzoic acid

Product 1

HCID 71252314HCID 71252314, compoundYield 35%

Procedure

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-methanesulfonylbenzoic acid (189 mg) described in Preparation Example 22 and 1-(2,6-dimethylpyridin-3-yl)piperazine (113 mg) described in Preparation Example 94 and by the reaction and treatment in the same manner as in Example 87, the title compound (102 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 94 and by the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-9135a7c6aa1247b2b50c4e9a5c1b255b
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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