反应详情

温度

-78 °C

[4-(2,4-Dimethylphenyl)piperazin-1-yl][4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-methoxyphenyl]methanone (0.35 g) described in Example 89 was dissolved in dichloromethane (20 mL), 1 mol/L boron tribromide dichloromethane solution (4 mL) was added while stirring at −78° C. under cooling, and the mixture was stirred while rising the temperature to room temperature. Into the reaction mixture was poured ice water, and the mixture was neutralized with sodium hydrogen carbonate and extracted with chloroform. The organic layer was washed with saturated brine, and the solvent was evaporated. The obtained residue was purified by column chromatography (chloroform:methanol) to give the title compound (168 mg).

1. temperatureunder cooling
2. stirringthe mixture was stirred
3. customto room temperature
4. extractionextracted with chloroform
5. washThe organic layer was washed with saturated brine
6. customthe solvent was evaporated
7. customThe obtained residue was purified by column chromatography (chloroform:methanol)