(R)-3-methylisothiazolidine 1,1-dioxide → HCID 71252270, compound

HRID 2411525Notes

Reaction equation

HRID 2411525 reaction equation
[F:1][C:2]1[CH:7]=[C:6](I)[CH:5]=[C:4]([F:9])[C:3]=1[C:10]([N:12]1[CH2:17][CH2:16][N:15]([C:18]2[C:23]([CH3:24])=[CH:22][C:21]([CH3:25])=[CH:20][N:19]=2)[CH2:14][CH2:13]1)=[O:11].[CH3:26][C@@H:27]1[CH2:31][CH2:30][S:29](=[O:33])(=[O:32])[NH:28]1>>[F:1][C:2]1[CH:7]=[C:6]([N:28]2[C@H:27]([CH3:26])[CH2:31][CH2:30][S:29]2(=[O:33])=[O:32])[CH:5]=[C:4]([F:9])[C:3]=1[C:10]([N:12]1[CH2:17][CH2:16][N:15]([C:18]2[C:23]([CH3:24])=[CH:22][C:21]([CH3:25])=[CH:20][N:19]=2)[CH2:14][CH2:13]1)=[O:11]

Participants

3

Reactant 2

HCID 16664802(R)-3-methylisothiazolidine 1,1-dioxideHCID 71252509HCID 71252509, compound

Product 1

HCID 71252270HCID 71252270, compoundYield 55.8%

Procedure

Using (2,6-difluoro-4-iodophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (743 mg) described in Preparation Example 158 and (R)-3-methylisothiazolidine 1,1-dioxide (220 mg) described in Preparation Example 2 and by the reaction and treatment in the same manner as in Example 1, the title compound (421 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 2 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-16d14fa961b646a8b6de81661e3d1cf4
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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