1,3-Propanesultam → [4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-methylphenyl]methanone

HRID 2411528Notes

Reaction equation

HRID 2411528 reaction equation
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20](I)=[CH:19][C:18]=3[CH3:24])=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[S:25]1(=[O:31])(=[O:30])[CH2:29][CH2:28][CH2:27][NH:26]1>>[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:26]4[CH2:27][CH2:28][CH2:29][S:25]4(=[O:31])=[O:30])=[CH:19][C:18]=3[CH3:24])=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

3

Reactant 2

HCID 6421571,3-PropanesultamHCID 71252193[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodo-2-methylphenyl)methanone

Product 1

HCID 71252659[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-methylphenyl]methanoneYield 58.2%

Procedure

Using [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl](4-iodo-2-methylphenyl)methanone (487 mg) described in Preparation Example 154 and isothiazolidine 1,1-dioxide (136 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (279 mg) was obtained.

Sources & evidence

ORD record
ord-29370ae1e6524b82a371ddc271324994
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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