HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Propanesultam → [4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-methylphenyl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Propanesultam | HCID 642157 | — |
| Reactant | [4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodo-2-methylphenyl)methanone | HCID 71252193 | — |
| Product | [4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-methylphenyl]methanone | HCID 71252659 | 58.2% |
Reaction Steps
Using [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl](4-iodo-2-methylphenyl)methanone (487 mg) described in Preparation Example 154 and isothiazolidine 1,1-dioxide (136 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (279 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-29370ae1e6524b82a371ddc271324994 |
| Source note | uspto-grants-2014_08 |