1-(3-Methyl-5-trifluoromethylpyridin-2-yl)piperazine → HCID 71251863, compound

HRID 2411548Notes

Reaction equation

HRID 2411548 reaction equation
[O:1]=[S:2]1(=[O:20])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[C:9]([S:16]([CH3:19])(=[O:18])=[O:17])[CH:8]=1.[CH3:21][C:22]1[C:23]([N:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)=[N:24][CH:25]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:27]=1>>[O:20]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([N:35]2[CH2:36][CH2:37][N:32]([C:23]3[C:22]([CH3:21])=[CH:27][C:26]([C:28]([F:31])([F:29])[F:30])=[CH:25][N:24]=3)[CH2:33][CH2:34]2)=[O:13])=[C:9]([S:16]([CH3:19])(=[O:18])=[O:17])[CH:8]=1

Participants

3

Reactant 2

HCID 584847291-(3-Methyl-5-trifluoromethylpyridin-2-yl)piperazineHCID 712521084-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-methanesulfonylbenzoic acid

Product 1

HCID 71251863HCID 71251863, compoundYield 82.2%

Procedure

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-methanesulfonylbenzoic acid (319 mg) described in Preparation Example 22 and 1-(3-methyl-5-trifluoromethylpyridin-2-yl)piperazine (245 mg) described in Preparation Example 84 and by the reaction and treatment in the same manner as in Example 87, the title compound (449 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 84 and by the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-820947c999684dd1bf04cd1a51ed9f7c
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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