1-(3,5,6-Trimethylpyridin-2-yl)piperazine → HCID 71252439, compound

HRID 2411549Notes

Reaction equation

HRID 2411549 reaction equation
[O:1]=[S:2]1(=[O:17])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[C:9]([F:16])[CH:8]=1.[CH3:18][C:19]1[C:20]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[N:21][C:22]([CH3:26])=[C:23]([CH3:25])[CH:24]=1>>[O:17]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([N:30]2[CH2:31][CH2:32][N:27]([C:20]3[C:19]([CH3:18])=[CH:24][C:23]([CH3:25])=[C:22]([CH3:26])[N:21]=3)[CH2:28][CH2:29]2)=[O:13])=[C:9]([F:16])[CH:8]=1

Participants

3

Reactant 2

HCID 584848231-(3,5,6-Trimethylpyridin-2-yl)piperazineHCID 712528614-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-fluorobenzoic acid

Product 1

HCID 71252439HCID 71252439, compoundYield 63.2%

Procedure

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-fluorobenzoic acid (259 mg) described in Preparation Example 23 and 1-(3,5,6-trimethylpyridin-2-yl)piperazine (205 mg) described in Preparation Example 92 and by the reaction and treatment in the same manner as in Example 87, the title compound (282 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 92 and by the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-b5f0e015c03d4faea90aa30ed10e8ae9
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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