1-(3-Cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine → HCID 71252417, compound

HRID 2411553Notes

Reaction equation

HRID 2411553 reaction equation
[O:1]=[S:2]1(=[O:20])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[C:9]([S:16]([CH3:19])(=[O:18])=[O:17])[CH:8]=1.[CH:21]1([C:24]2[C:25]([N:34]3[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]3)=[N:26][CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=2)[CH2:23][CH2:22]1>>[CH:21]1([C:24]2[C:25]([N:34]3[CH2:39][CH2:38][N:37]([C:11]([C:10]4[CH:14]=[CH:15][C:7]([N:3]5[CH2:4][CH2:5][CH2:6][S:2]5(=[O:1])=[O:20])=[CH:8][C:9]=4[S:16]([CH3:19])(=[O:18])=[O:17])=[O:13])[CH2:36][CH2:35]3)=[N:26][CH:27]=[C:28]([C:30]([F:33])([F:31])[F:32])[CH:29]=2)[CH2:22][CH2:23]1

Participants

3

Reactant 2

HCID 584847721-(3-Cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazineHCID 71252108HCID 71252108, compound

Product 1

HCID 71252417HCID 71252417, compoundYield 79.5%

Procedure

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-methanesulfonylbenzoic acid (319 mg) described in Preparation Example 22 and 1-(3-cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine (271 mg) described in Preparation Example 90 and by the reaction and treatment in the same manner as in Example 87, the title compound (455 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 90 and by the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-780f4f532eb94c648b2e7898e5ea3feb
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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