HRID2411553

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID58484772

未命名化合物

结构：CS(=O)(=O)c1cc(N2CCCS2(=O)=O)ccc1C(=O)O

HCID71252108

未命名化合物

PRODUCTS

生成物

结构：CS(=O)(=O)c1cc(N2CCCS2(=O)=O)ccc1C(=O)N1CCN(c2ncc(C(F)(F)F)cc2C2CC2)CC1

HCID71252417

未命名化合物

收率 79.5%

PROCEDURE

实验过程

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-methanesulfonylbenzoic acid (319 mg) described in Preparation Example 22 and 1-(3-cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine (271 mg) described in Preparation Example 90 and by the reaction and treatment in the same manner as in Example 87, the title compound (455 mg) was obtained.

WORKUP

后处理

customdescribed in Preparation Example 90 and by the reaction and treatment in the same manner as in Example 87

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-780f4f532eb94c648b2e7898e5ea3feb
来源数据集: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08816079B2
来源说明: uspto-grants-2014_08

反应 SMILES

[O:1]=[S:2]1(=[O:20])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[C:9]([S:16]([CH3:19])(=[O:18])=[O:17])[CH:8]=1.[CH:21]1([C:24]2[C:25]([N:34]3[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]3)=[N:26][CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=2)[CH2:23][CH2:22]1>>[CH:21]1([C:24]2[C:25]([N:34]3[CH2:39][CH2:38][N:37]([C:11]([C:10]4[CH:14]=[CH:15][C:7]([N:3]5[CH2:4][CH2:5][CH2:6][S:2]5(=[O:1])=[O:20])=[CH:8][C:9]=4[S:16]([CH3:19])(=[O:18])=[O:17])=[O:13])[CH2:36][CH2:35]3)=[N:26][CH:27]=[C:28]([C:30]([F:33])([F:31])[F:32])[CH:29]=2)[CH2:22][CH2:23]1