1-(3-Cyclopropyl-5-methylpyridin-2-yl)piperazine → HCID 71252426, compound

HRID 2411556Notes

Reaction equation

HRID 2411556 reaction equation
[CH3:1][S:2]([C:5]1[CH:15]=[C:14]([N:16]2[C@H:20]([CH3:21])[CH2:19][CH2:18][S:17]2(=[O:23])=[O:22])[CH:13]=[CH:12][C:6]=1[C:7](OCC)=[O:8])(=[O:4])=[O:3].[CH:24]1([C:27]2[C:28]([N:34]3[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]3)=[N:29][CH:30]=[C:31]([CH3:33])[CH:32]=2)[CH2:26][CH2:25]1>>[CH:24]1([C:27]2[C:28]([N:34]3[CH2:39][CH2:38][N:37]([C:7]([C:6]4[CH:12]=[CH:13][C:14]([N:16]5[C@H:20]([CH3:21])[CH2:19][CH2:18][S:17]5(=[O:22])=[O:23])=[CH:15][C:5]=4[S:2]([CH3:1])(=[O:3])=[O:4])=[O:8])[CH2:36][CH2:35]3)=[N:29][CH:30]=[C:31]([CH3:33])[CH:32]=2)[CH2:25][CH2:26]1

Participants

3

Reactant 2

HCID 584846211-(3-Cyclopropyl-5-methylpyridin-2-yl)piperazineHCID 71261164ethyl (R)-2-methanesulfonyl-4-(3-methyl-1,1-dioxo-1lambda6-isothiazolidin-2-yl)benzoate

Product 1

HCID 71252426HCID 71252426, compoundYield 75.7%

Procedure

Using ethyl (R)-2-methanesulfonyl-4-(3-methyl-1,1-dioxo-1λ6-isothiazolidin-2-yl)benzoate (181 mg) described in Preparation Example 28 and 1-(3-cyclopropyl-5-methylpyridin-2-yl)piperazine (109 mg) described in Preparation Example 86 and by the reaction and treatment in the same manner as in Example 109, the title compound (202 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 86 and by the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-63d77e68be884e12ad54a088bda1db80
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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