1-(3-Cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine → HCID 71252559, compound

HRID 2411562Notes

Reaction equation

HRID 2411562 reaction equation
[O:1]=[S:2]1(=[O:23])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][S:17]2(=[O:22])=[O:21])[CH:13]=[CH:12][C:8]=1[C:9](O)=[O:10].[CH:24]1([C:27]2[C:28]([N:37]3[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]3)=[N:29][CH:30]=[C:31]([C:33]([F:36])([F:35])[F:34])[CH:32]=2)[CH2:26][CH2:25]1>>[O:23]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][S:17]2(=[O:21])=[O:22])[CH:13]=[CH:12][C:8]=1[C:9]([N:40]1[CH2:41][CH2:42][N:37]([C:28]2[C:27]([CH:24]3[CH2:25][CH2:26]3)=[CH:32][C:31]([C:33]([F:36])([F:34])[F:35])=[CH:30][N:29]=2)[CH2:38][CH2:39]1)=[O:10]

Participants

3

Reactant 2

HCID 584847721-(3-Cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazineHCID 71252293HCID 71252293, compound

Product 1

HCID 71252559HCID 71252559, compoundYield 47.2%

Procedure

Using 2,4-bis(1,1-dioxo-1λ6-isothiazolidin-2-yl)benzoic acid (200 mg) described in Preparation Example 34 and 1-(3-cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine (150 mg) described in Preparation Example 90 and by the reaction and treatment in the same manner as in Example 87, the title compound (160 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 90 and by the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-3ff0675e6f324b1badaf76ef4c8c7b02
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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