1-(3,5-Dicyclopropylpyridin-2-yl)piperazine hydrochloride → [4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-methoxyphenyl]methanone

HRID 2411569Notes

Reaction equation

HRID 2411569 reaction equation
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[C:9]([O:16][CH3:17])[CH:8]=1.Cl.[CH:20]1([C:23]2[C:24]([N:32]3[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]3)=[N:25][CH:26]=[C:27]([CH:29]3[CH2:31][CH2:30]3)[CH:28]=2)[CH2:22][CH2:21]1>>[CH:20]1([C:23]2[C:24]([N:32]3[CH2:33][CH2:34][N:35]([C:11]([C:10]4[CH:14]=[CH:15][C:7]([N:3]5[CH2:4][CH2:5][CH2:6][S:2]5(=[O:1])=[O:18])=[CH:8][C:9]=4[O:16][CH3:17])=[O:13])[CH2:36][CH2:37]3)=[N:25][CH:26]=[C:27]([CH:29]3[CH2:31][CH2:30]3)[CH:28]=2)[CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 673810941-(3,5-Dicyclopropylpyridin-2-yl)piperazine hydrochlorideHCID 712520824-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-methoxybenzoic acid

Product 1

HCID 71252621[4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-methoxyphenyl]methanoneYield 69.9%

Procedure

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-methoxybenzoic acid (271 mg) described in Preparation Example 19 and 1-(3,5-dicyclopropylpyridin-2-yl)piperazine hydrochloride (316 mg) described in Preparation Example 87 and by the reaction and treatment in the same manner as in Example 86, the title compound (347 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 87 and by the reaction and treatment in the same manner as in Example 86

Sources & evidence

ORD record
ord-ec9c55dfd031441986fc08b7d08fae4f
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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