Tetrahydrofuran → [4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-methylphenyl]methanone hydrobromide

HRID 2411581Notes

Reaction equation

HRID 2411581 reaction equation
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:27][CH2:26][CH2:25][S:24]4(=[O:29])=[O:28])=[CH:19][C:18]=3[CH3:30])=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[BrH:31].C(O)(=O)C.O1CCCC1>C(O)(=O)C>[BrH:31].[CH3:1][C:2]1[C:3]([N:9]2[CH2:10][CH2:11][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:27][CH2:26][CH2:25][S:24]4(=[O:29])=[O:28])=[CH:19][C:18]=3[CH3:30])=[O:16])[CH2:13][CH2:14]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 21893785Acetic Acid Mixture with Hydrobromic AcidHCID 71252659[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-methylphenyl]methanone

Product 1

HCID 86676782[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-methylphenyl]methanone hydrobromide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl][4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-methylphenyl]methanone (5.00 g) described in Example 154 was dissolved in acetic acid (20 mL), and 25% hydrogen bromide/acetic acid (3.3 mL) was added at 50° C. The reaction mixture was allowed to cool to room temperature, tetrahydrofuran (200 mL) was added, and the precipitate was collected by filtration. The obtained precipitate (5.52 g) was recrystallized from ethanol (110 mL) to give the title compound (4.67 g).

Workup

  1. filtrationthe precipitate was collected by filtration
  2. customThe obtained precipitate (5.52 g) was recrystallized from ethanol (110 mL)

Sources & evidence

ORD record
ord-a886670ccd334cfd9165706df49c0692
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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