Hydrochloric Acid → HCID 71252574, compound

HRID 2411589Notes

Reaction equation

HRID 2411589 reaction equation
[O:1]=[S:2]1(=[O:32])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:31]=[CH:30][C:10]([C:11]([N:13]2[CH2:18][CH2:17][N:16]([C:19]3[CH:28]=[CH:27][C:22]([C:23]([O:25]C)=[O:24])=[CH:21][C:20]=3[CH3:29])[CH2:15][CH2:14]2)=[O:12])=[CH:9][CH:8]=1.[OH-].[Na+].Cl>CO>[O:32]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:31]=[CH:30][C:10]([C:11]([N:13]2[CH2:18][CH2:17][N:16]([C:19]3[CH:28]=[CH:27][C:22]([C:23]([OH:25])=[O:24])=[CH:21][C:20]=3[CH3:29])[CH2:15][CH2:14]2)=[O:12])=[CH:9][CH:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 71251928HCID 71251928, compound

Product 1

HCID 71252574HCID 71252574, compoundYield 86.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

Methyl 4-{4-[4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)benzoyl]piperazin-1-yl}-3-methylbenzoate (1.01 g) described in Example 217 was dissolved in methanol (8 mL), 1N aqueous sodium hydroxide solution (3.3 mL) was added, and the mixture was stirred at 60° C. for 4 hr. The reaction mixture was cooled and neutralized with dilute hydrochloric acid, and the precipitate was collected by filtration to give the title compound (844 mg).

Workup

  1. temperatureThe reaction mixture was cooled
  2. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-f36e5c30901b4c838db44b3bb8f6f60d
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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