3-Chloropropanesulphonyl chloride → HCID 71252083, compound

HRID 2411597Notes

Reaction equation

HRID 2411597 reaction equation
CC1C=C(C)C=CC=1N1CCN(C(C2C=NC(F)=CC=2C)=O)CC1.COC1C=CC(CN)=CC=1.[Cl:35]CCCS(Cl)(=O)=O.NC1N=CC(C(N2CCN(C3C=CC(C)=CC=3C)CC2)=O)=C(C)C=1.[CH3:67][C:68]1[CH:73]=[C:72]([CH3:74])[CH:71]=[CH:70][C:69]=1[N:75]1[CH2:80][CH2:79][N:78]([C:81]([C:83]2[CH:84]=[N:85][C:86]([N:90]3[CH2:94][CH2:93][CH2:92][S:91]3(=[O:96])=[O:95])=[CH:87][C:88]=2[CH3:89])=[O:82])[CH2:77][CH2:76]1>>[ClH:35].[CH3:67][C:68]1[CH:73]=[C:72]([CH3:74])[CH:71]=[CH:70][C:69]=1[N:75]1[CH2:76][CH2:77][N:78]([C:81]([C:83]2[CH:84]=[N:85][C:86]([N:90]3[CH2:94][CH2:93][CH2:92][S:91]3(=[O:96])=[O:95])=[CH:87][C:88]=2[CH3:89])=[O:82])[CH2:79][CH2:80]1

Participants

6

Reactant 5

HCID 154103-Chloropropanesulphonyl chlorideHCID 754524-MethoxybenzylamineHCID 58484738HCID 58484738, compoundHCID 71252084[4-(2,4-Dimethylphenyl)piperazin-1-yl][6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-4-methylpyridin-3-yl]methanoneHCID 71252778HCID 71252778, compound

Product 1

HCID 71252083HCID 71252083, compound

Procedure

Using [4-(2,4-dimethylphenyl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone (470 mg) described in Preparation Example 175, 4-methoxybenzylamine (1 mL) and 3-chloropropane-1-sulfonyl chloride (0.20 mL) and by the reaction and treatment in the same manner as in Example 223, the title compound (485 mg) was obtained via (6-amino-4-methylpyridin-3-yl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone and [4-(2,4-dimethylphenyl)piperazin-1-yl][6-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-4-methylpyridin-3-yl]methanone.

Sources & evidence

ORD record
ord-8f6e2d9a88244900a188d6cc53111424
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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