反应详情

Using [4-(2,4-dimethylphenyl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone (470 mg) described in Preparation Example 175, 4-methoxybenzylamine (1 mL) and 3-chloropropane-1-sulfonyl chloride (0.20 mL) and by the reaction and treatment in the same manner as in Example 223, the title compound (485 mg) was obtained via (6-amino-4-methylpyridin-3-yl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone and [4-(2,4-dimethylphenyl)piperazin-1-yl][6-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-4-methylpyridin-3-yl]methanone.