1-(3-Cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine → HCID 71252474, compound

HRID 2411604Notes

Reaction equation

HRID 2411604 reaction equation
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:17]=[CH:16][C:10]([C:11]([O:13]CC)=O)=[CH:9][N:8]=1.[CH:19]1([C:22]2[C:23]([N:32]3[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]3)=[N:24][CH:25]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:27]=2)[CH2:21][CH2:20]1>>[CH:19]1([C:22]2[C:23]([N:32]3[CH2:37][CH2:36][N:35]([C:11]([C:10]4[CH:9]=[N:8][C:7]([N:3]5[CH2:4][CH2:5][CH2:6][S:2]5(=[O:1])=[O:18])=[CH:17][CH:16]=4)=[O:13])[CH2:34][CH2:33]3)=[N:24][CH:25]=[C:26]([C:28]([F:31])([F:29])[F:30])[CH:27]=2)[CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 584847721-(3-Cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazineHCID 71251937Ethyl 6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)nicotinate

Product 1

HCID 71252474HCID 71252474, compoundYield 68.2%

Procedure

Using ethyl 6-(1,1-dioxo-1λ6-isothiazolidin-2-yl)nicotinate (300 mg) described in Preparation Example 25 and 1-(3-cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine (331 mg) described in Preparation Example 90 and by the reaction and treatment in the same manner as in Example 109, the title compound (375 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 90 and by the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-54360b50290e4249bb0b9e124a4f6a33
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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