HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine → HCID 71252474, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine | HCID 58484772 | — |
| Reactant | Ethyl 6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)nicotinate | HCID 71251937 | — |
| Product | HCID 71252474 | HCID 71252474 | 68.2% |
Reaction Steps
Using ethyl 6-(1,1-dioxo-1λ6-isothiazolidin-2-yl)nicotinate (300 mg) described in Preparation Example 25 and 1-(3-cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine (331 mg) described in Preparation Example 90 and by the reaction and treatment in the same manner as in Example 109, the title compound (375 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-54360b50290e4249bb0b9e124a4f6a33 |
| Source note | uspto-grants-2014_08 |